منابع مشابه
Mutated Fanconi anemia pathway in non-Fanconi anemia cancers
An extremely high cancer incidence and the hypersensitivity to DNA crosslinking agents associated with Fanconi Anemia (FA) have marked it to be a unique genetic model system to study human cancer etiology and treatment, which has emerged an intense area of investigation in cancer research. However, there is limited information about the relationship between the mutated FA pathway and the cancer...
متن کاملThe Fanconi Anemia Pathway of Genomic Maintenance
Fanconi anemia (FA), a recessive syndrome with both autosomal and X-linked inheritance, features diverse clinical symptoms, such as progressive bone marrow failure, hypersensitivity to DNA cross-linking agents, chromosomal instability and susceptibility to cancer. At least 12 genetic subtypes have been described (FA-A, B, C, D1, D2, E, F, G, I, J, L, M) and all except FA-I have been linked to a...
متن کاملUbiquitin-like protein UBL5 promotes the functionality of the Fanconi anemia pathway
Thank you for submitting your manuscript on UBL5 in the Fanconi Anemia pathway to The EMBO Journal. We have now received the reports from four expert referees, which you will find copied below. All four referees find the study interesting and potentially important, and we would therefore be interested in considering a revised version further for publication. As you will see, the reviewers do ho...
متن کاملUbiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.
Ubiquitin and ubiquitin-like proteins (UBLs) function in a wide array of cellular processes. UBL5 is an atypical UBL that does not form covalent conjugates with cellular proteins and which has a known role in modulating pre-mRNA splicing. Here, we report an unexpected involvement of human UBL5 in promoting the function of the Fanconi anemia (FA) pathway for repair of DNA interstrand crosslinks ...
متن کاملRegulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.
The Fanconi anemia (FA)-BRCA pathway is critical for the repair of DNA interstrand crosslinks (ICLs) and the maintenance of chromosome stability. A key step in FA-BRCA pathway activation is the covalent attachment of monoubiquitin to FANCD2 and FANCI. Monoubiquitinated FANCD2 and FANCI localize in chromatin-associated nuclear foci where they interact with several well-characterized DNA repair p...
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ژورنال
عنوان ژورنال: BMC Biochemistry
سال: 2007
ISSN: 1471-2091
DOI: 10.1186/1471-2091-8-s1-s10